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Our Expertise
Solubility Issues
A limiting factor for many new drug candidates, we use the following approaches to increase the solubility of molecules:
- Solubility enhancing excipients
- Spray drying to produce amorphous API or dispersions
- Amorphous solid dispersions
- Milling and nanomilling
- Lipid nanoparticles and liposomes
Permeability Issues
To overcome permeability issues, we use multiple approaches, including:
- Permeability enhancing excipients
- Lipid nanoparticles and liposomes
- Cell penetrating peptides
- Pertinent for indications such as Alzheimer's or Parkinson's disease and drugs targeting the central nervous system.
Extending Your Molecule's Release Profile
To extend, sustain or modify the release profile of formulations, we use the following approaches:
- Size reduction using milling or nanomilling
- Matrix formation using polymers to slow release of the drug
- Coasting of particles, granules, capsules or tablets
- Layering of components within the drug product
Formulation Types
We can develop and supply a variety of formulation types including:
- Tablets, capsules, caplets and lozenges: Immediate, modified and sustained release
- Liquids and suspensions: Oral, IV, ocular, and nanosuspensions
- Lipid nanoparticles and liposomes
- Creams, gels and ointments
- Powder blends
Routes of Administration
We have demonstrated expertise in making formulations for the following routes of administration:
- Oral: Tablet, caplets, capsules, solutions, suspensions and nanosuspensions
- Buccal and sublingual: Tablets and lozenges
- Subcutaneous: Solutions, suspensions and depots
- Intranasal: Gels and solutions, particularly for crossing the blood brain barrier
- Ocular: Gels, solutions, nano suspensions and IVTs
- Intravenous: Solutions and depots
- Transdermal: Creams, gels and ointments
Analytical Method Development
In order to demonstrate our formulation approaches are effective:
- We develop and appropriately validate analytical methods specific to the molecule.
- We also develop and validate HPLC methods as part of formulation projects, or as standalone projects.
Consulting